The article is devoted to a number of methodological aspects related to the assessment of regional investment attractiveness. The concept of “regional investment attractiveness” as a broad economic category covering the whole complex of external factors which influence the risk and return of investment projects under implementation in the region is considered. The author presents a list of the stages of investment attractiveness assessment and analyzes methodological difficulties encountered in each of these stages. Special attention is paid to the process of weighing investment attractiveness factors. This process is one of the key stages of assessment, and the correctness of such weighing influences the quality of the integral index of regional investment attractiveness.